Methylation status of the CpG islands in vitamin D and calcium-sensing receptor gene promoters does not explain the reduced gene expressions in parathyroid adenomas
Journal of Clinical Endocrinology and Metabolism, 08/05/2013
Varshney S et al. – The exact mechanism causing decreased expression of the vitamin D receptor (VDR) and calcium–sensing receptor (CASR) genes in parathyroid adenoma is not known, but methylation of promoter regions is often detected during epigenetic downregulation of gene expression. The authors investigated whether epigenetic silencing is involved in the decreased expression of VDR and CASR. Methylation–mediated silencing of VDR and CASR promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of VDR and CASR in parathyroid adenomas.