Nut consumption with risk of hypertension and type 2 diabetes mellitus: A meta-analysis of prospective cohort studies
European Journal of Preventive Cardiology, 08/12/2013
Guo K et al. – The aim of this study was to systematically examine longitudinal studies investigating nut intake in relation to risk of hypertension and type 2 diabetes mellitus (T2DM). In the meta–analysis, nut consumption is found to be inversely associated with hypertension risk but is not associated with the risk of T2DM.
- A systematic search of the PubMed and EMBASE databases to 31 March 2013 was performed.
- Reference lists of retrieved articles were also screened.
- Summary relative risks (SRRs) and 95% confidence intervals (CIs) were calculated using a random-effects model.
- Q and I2 statistics were used to examine between-study heterogeneity.
- A total of nine prospective cohort studies (three for hypertension and six for T2DM) were identified.
- Using random effects models, the authors found that based on the highest vs lowest analysis, nut consumption were inversely associated with risk of hypertension (SRR = 0.84, 95% CI: 0.76–0.93, pheterogeneity = 0.831, I2 = 0%).
- Dose-response analyses indicated that nut consumption at more than two servings/wk, but not ne serving/wk, had a preventative role in the hypertension.
- In addition, nut consumption was not associated with risk of T2DM (SRRs = 0.98, 95% CI: 0.84–1.15; pheterogeneity = 0.008, I2 = 67.7%) on the basis of the highest vs lowest analysis.
- This null association was also shown in the dose-response analysis.